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Article Dans Une Revue Pathogens Année : 2021

Presence of SARS-CoV-2 in a Cornea Transplant

Résumé

Background: The SARS-CoV-2 pandemic has impacted tissue transplantation procedures since conjunctivas were found to be associated with coronavirus infection. Here, we investigated infection of a cornea graft from a COVID-19-positive donor. Methods: In order to evaluate the presence of SARS-CoV-2 in the cornea graft we first carried out a qRT-PCR and then we investigated the presence of SARS-CoV-2 by fluorescence and electron microscopy. Conclusions: Although the cornea graft was found to be negative by qRT-PCR, we were able to show the presence of SARS-CoV-2 in corneal cells expressing the SARS-CoV-2 receptor, ACE2. Taken together, our findings may have important implications for the use of corneal tissue in graft indications and open the debate on SARS-CoV-2 transmissibility.

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hal-03329562 , version 1 (29-06-2023)

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Myriem Otmani Idrissi, Jean-Pierre Baudoin, Anne-Line Chateau, Sarah Aherfi, Marielle Bedotto-Buffet, et al.. Presence of SARS-CoV-2 in a Cornea Transplant. Pathogens, 2021, 10 (8), pp.934. ⟨10.3390/pathogens10080934⟩. ⟨hal-03329562⟩
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