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Journal Articles ACS Central Science Year : 2021

Molecular Aspects Concerning the Use of the SARS-CoV-2 Receptor Binding Domain as a Target for Preventive Vaccines

Yury Valdes-Balbin
  • Function : Author
Darielys Santana-Mederos
  • Function : Author
Françoise Paquet
Sonsire Fernandez
  • Function : Author
Yanet Climent
  • Function : Author
Fabrizio Chiodo
Laura Rodríguez
  • Function : Author
Belinda Sanchez Ramirez
  • Function : Author
Kalet Leon
  • Function : Author
Tays Hernandez
  • Function : Author
Lila Castellanos-Serra
  • Function : Author
Raine Garrido
  • Function : Author
Guang-Wu Chen
  • Function : Author
Dagmar Garcia-Rivera
  • Function : Author
Daniel Rivera
Vicente Verez-Bencomo
  • Function : Author

Abstract

The development of recombinant COVID-19 vaccines has resulted from scientific progress made at an unprecedented speed during 2020. The recombinant spike glycoprotein monomer, its trimer, and its recombinant receptor-binding domain (RBD) induce a potent anti-RBD neutralizing antibody response in animals. In COVID-19 convalescent sera, there is a good correlation between the antibody response and potent neutralization. In this review, we summarize with a critical view the molecular aspects associated with the interaction of SARS-CoV-2 RBD with its receptor in human cells, the angiotensin-converting enzyme 2 (ACE2), the epitopes involved in the neutralizing activity, and the impact of virus mutations thereof. Recent trends in RBD-based vaccines are analyzed, providing detailed insights into the role of antigen display and multivalence in the immune response of vaccines under development.
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Dates and versions

hal-03327027 , version 1 (19-11-2021)

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Yury Valdes-Balbin, Darielys Santana-Mederos, Françoise Paquet, Sonsire Fernandez, Yanet Climent, et al.. Molecular Aspects Concerning the Use of the SARS-CoV-2 Receptor Binding Domain as a Target for Preventive Vaccines. ACS Central Science, 2021, 7 (5), pp.757-767. ⟨10.1021/acscentsci.1c00216⟩. ⟨hal-03327027⟩
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