Gold(III) porphyrins: Synthesis and interaction with G-quadruplex DNA - Archive ouverte HAL Access content directly
Journal Articles Journal of Inorganic Biochemistry Year : 2021

Gold(III) porphyrins: Synthesis and interaction with G-quadruplex DNA

Abstract

G-quadruplex nucleic acids (G4s) are RNA and DNA secondary structures involved in the regulation of multiple key biological processes. They can be found in telomeres, oncogene promoters, RNAs, but also in viral genomes. Due to their unique structural features, very distinct from the canonical duplexes or single-strands, G4s represent promising pharmacological targets for small molecules, namely G4-ligands. Gold(III) penta-cationic porphyrins, as specific G4 ligands, are able to inhibit HIV-1 infectivity and their antiviral activity correlates with their affinity for G4s. Up to now, one of the best antiviral compounds is meso-5,10,15,20-tetrakis[4-(N-methyl-pyridinium-2-yl)phenyl]porphyrinato gold(III) (1). Starting from this compound, we report a structure/affinity relationship study of gold(III) cationic porphyrins to find out the best porphyrin candidate for functionalization, in order to study the antiviral mechanism of action of these gold(III) porphyrins.
Fichier principal
Vignette du fichier
Rundstadler J Inorg Biochem 2021_HAL.pdf (1.25 Mo) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-03312437 , version 1 (02-08-2021)

Identifiers

Cite

Tiffany Rundstadler, Emmanuelle Mothes, Samir Amrane, Jean-Luc Stigliani, Pierre Verhaeghe, et al.. Gold(III) porphyrins: Synthesis and interaction with G-quadruplex DNA. Journal of Inorganic Biochemistry, 2021, 223, pp.111551. ⟨10.1016/j.jinorgbio.2021.111551⟩. ⟨hal-03312437⟩
62 View
56 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More