EtROP2 is an early expressed kinase localisated in the rhoptry compartment of Eimeria tenella - Archive ouverte HAL Accéder directement au contenu
Poster De Conférence Année : 2019

EtROP2 is an early expressed kinase localisated in the rhoptry compartment of Eimeria tenella

Alix Sausset
Yves Le Vern
Fabrice Laurent
Sonia Lacroix-Lamandé
Anne Silvestre

Résumé

Coccidia are obligate intracellular parasites responsible for human and veterinary diseases. Eimeria tenella is an apicomplexan protozoan which is responsible for avian coccidiosis. This pathology induces a major economic loss for poultry industry worldwide. The parasite invades the digestive epithelial cells, which cause intestinal lesion that can lead to death. Until today, prophylaxis permitted to fight against coccidiosis by using chemotherapy and vaccination. But, with the apparition of resistance against anticoccidian molecules and with the high cost of vaccines, it appears necessary to improve these means of control. During invasion, the parasite releases the content of rhoptries, apicomplexan specific secretory organelles. Toxoplasma gondii rhoptry protein repertoire includes kinases that are key virulence factors. Kinases are involved in the molecular dialogue between the parasite and host cell. This involvement allows them to modulate cellular functions and pathways allowing T. gondii development. E. tenella kinome is predicted to contain 28 putative ROP kinases. Among them, two predicted kinases were identified in the rhoptry proteome of E. tenella sporozoites. The first kinase EtROP1 is described as an active kinase that phosphorylates the p53 inhibiting the apoptosis of parasited cells and thus promoting the parasite development. The second kinase EtROP2 is an active kinase whose functions need to be characterized. This work shows the apical localization of EtROP2 by microscopy techniques and his early expression in the parasite life cycle. The EtROP2 study may reveal it as a good candidate in the race for the improvement of the means of coccidiosis control.
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Dates et versions

hal-03307683 , version 1 (29-07-2021)

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  • HAL Id : hal-03307683 , version 1

Citer

Adeline Ribeiro E Silva, Alix Sausset, Yves Le Vern, Fabrice Laurent, Sonia Lacroix-Lamandé, et al.. EtROP2 is an early expressed kinase localisated in the rhoptry compartment of Eimeria tenella. ApiCOWplexa 2019. 5. International Meeting on Apicomplexan Parasites in Farm Animals, Oct 2019, Berlin, Germany. . ⟨hal-03307683⟩
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