First-in-class and best-in-class dendrimer nanoplatforms from concept to clinic: Lessons learned moving forward - Archive ouverte HAL Access content directly
Journal Articles European Journal of Medicinal Chemistry Year : 2021

First-in-class and best-in-class dendrimer nanoplatforms from concept to clinic: Lessons learned moving forward

Abstract

Research to develop active dendrimers by themselves or as nanocarriers represents a promising approach to discover new biologically active entities that can be used to tackle unmet medical needs including difficult diseases. These developments are possible due to the exceptional physicochemical properties of dendrimers, including their biocompatibility, as well as their therapeutic activity as nanocarriers and drugs themselves. Despite a large number of academic studies, very few dendrimers have crossed the ‘valley of death’ between. Only a few number of pharmaceutical companies have succeeded in this way. In fact, only Starpharma (Australia) and Orpheris, Inc. (USA), an Ashvattha Therapeutics subsidiary, can fill all the clinic requirements to have in the market dendrimers based drugs/nancocarriers. After evaluating the main physicochemical properties related to the respective biological activity of dendrimers classified as first-in-class or best-in-class in nanomedicine, this original review analyzes the advantages and disavantages of these two strategies as well the concerns to step in clinical phases. Various solutions are proposed to advance the use of dendrimers in human health.
Fichier principal
Vignette du fichier
S0223523421003056.pdf (1.17 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-03275575 , version 1 (24-04-2023)

Licence

Attribution - NonCommercial

Identifiers

Cite

Serge Mignani, Xangyang Shi, João Rodrigues, Helena Tomas, Andrii Karpus, et al.. First-in-class and best-in-class dendrimer nanoplatforms from concept to clinic: Lessons learned moving forward. European Journal of Medicinal Chemistry, 2021, 219, pp.113456. ⟨10.1016/j.ejmech.2021.113456⟩. ⟨hal-03275575⟩
15 View
4 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More