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Article Dans Une Revue Nano Today Année : 2020

Phosphorus dendrimer-based copper(II) complexes enable ultrasound-enhanced tumor theranostics

Résumé

Design of simple-component theranostic agents with enhanced tumor accumulation represents a novel strategy in the area of precision nanomedicine for effective tumor theranostics. Herein, we report an innovative theranostic strategy based on ultrasound-enhanced tumor accumulation of a theranostic agent of phosphorus dendrimer-copper(II) complexes (1G3-Cu). The employed 1G3-Cu complexes represent a drug-free nanotheranostic agent with a simple composition possessing an r1 relaxivity of 0.7024 mM−1 s−1 for T1-weighted magnetic resonance (MR) imaging and an IC50 of 1.24 μM to inhibit the growth of a pancreatic cancer cell line. We show that cancer cells can be inhibited by the 1G3-Cu complexes through the activation of the apoptotic process with the upregulation of Bax, P53 and PTEN, downregulation of Bcl-2, and decrease of intracellular ATP. With the assistance of ultrasound targeted microbubble destruction (UTMD) technology that can increase cell membrane permeability temporarily via sonoporation effect, the 1G3-Cu complexes enable enhanced tumor MR imaging and chemotherapy due to their improved tumor accumulation. With the proven minimal toxicity to normal tissues at imaging and therapeutic doses, the prepared 1G3-Cu complexes may be potentially employed for UTMD-enhanced theranostics of different types of cancer.
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Dates et versions

hal-03274915 , version 1 (30-06-2021)

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Yu Fan, Lizhou Lin, Fangfang Yin, Yu Zhu, Mingwu Shen, et al.. Phosphorus dendrimer-based copper(II) complexes enable ultrasound-enhanced tumor theranostics. Nano Today, 2020, 33, pp.100899. ⟨10.1016/j.nantod.2020.100899⟩. ⟨hal-03274915⟩
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