Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nature Immunology Année : 2014

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

Résumé

The paradigm that macrophages that reside in steady-state tissues are derived from embryonic precursors has never been investigated in the intestine, which contains the largest pool of macrophages. Using fate-mapping models and monocytopenic mice, together with bone marrow chimera and parabiotic models, we found that embryonic precursor cells seeded the intestinal mucosa and demonstrated extensive in situ proliferation during the neonatal period. However, these cells did not persist in the intestine of adult mice. Instead, they were replaced around the time of weaning by the chemokine receptor CCR2-dependent influx of Ly6C(hi) monocytes that differentiated locally into mature, anti-inflammatory macrophages. This process was driven largely by the microbiota and had to be continued throughout adult life to maintain a normal intestinal macrophage pool.

Dates et versions

hal-03263928 , version 1 (17-06-2021)

Identifiants

Citer

Calum Bain, Alberto Bravo-Blas, Charlotte Scott, Elisa Gomez Perdiguero, Frederic Geissmann, et al.. Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice. Nature Immunology, 2014, 15 (10), pp.929-937. ⟨10.1038/ni.2967⟩. ⟨hal-03263928⟩
22 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More