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Article Dans Une Revue Communications Biology Année : 2021

Lentiviral vector induces high-quality memory T cells via dendritic cells transduction

Résumé

We report a lentiviral vector harboring the human β2-microglobulin promoter, with predominant expression in immune cells and minimal proximal enhancers to improve vector safety. This lentiviral vector efficiently transduces major dendritic cell subsets in vivo. With a mycobacterial immunogen, we observed distinct functional signatures and memory phenotype in lentiviral vector- or Adenovirus type 5 (Ad5)-immunized mice, despite comparable antigen-specific CD8 + T cell magnitudes. Compared to Ad5, lentiviral vector immunization resulted in higher multifunctional and IL-2-producing CD8 + T cells. Furthermore, lentiviral vector immunization primed CD8 + T cells towards central memory phenotype, while Ad5 immunization favored effector memory phenotype. Studies using HIV antigens in outbred rats demonstrated additional clear-cut evidence for an immunogenic advantage of lentiviral vector over Ad5. Additionally, lentiviral vector provided enhance therapeutic anti-tumor protection than Ad5. In conclusion, coupling lentiviral vector with β2-microglobulin promoter represents a promising approach to produce long-lasting, high-quality cellular immunity for vaccinal purposes.

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Vaccinologie
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Origine : Publication financée par une institution

Dates et versions

hal-03261611 , version 1 (30-06-2021)

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Min Wen Ku, Pierre Authié, Fabien Nevo, Philippe Souque, M Bourgine, et al.. Lentiviral vector induces high-quality memory T cells via dendritic cells transduction. Communications Biology, 2021, 4, pp.713. ⟨10.1038/s42003-021-02251-6⟩. ⟨hal-03261611⟩

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