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Article Dans Une Revue Environmental Chemistry Letters Année : 2021

Backward transmission of COVID-19 from humans to animals may propagate reinfections and induce vaccine failure

Résumé

The coronavirus disease 2019 (COVID-19) pandemic is becoming the greatest public health crisis since the influenza pandemic in 1918. Indeed, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to 219 countries and regions, causing over 46.5 million human infections including more than 1.2 million deaths as of November 3, 2020. So far, research has focused on its transmission from animals to humans - 'zoonosis' - to explain its spillover to humans, yet its further transmission from humans to animals - 'anthroponosis' or 'reverse zoonosis' - has been much less considered. Knowledge concerning the relationships between its human and animal hosts is still limited, and a consensus has yet to be reached on the animal origin of COVID-19. SARS-CoV-2 shares 79.6% of its genome sequences with SARS-CoV-1, a strain that has infected humans, bats and palm civets in 2003. Also, SARS-CoV-2 shares 96.2% of its sequences with a bat coronavirus isolated from Rhinolophus affinis, suggesting that bats may be the natural hosts of SARS-CoV-2. Cats, ferrets, minks, pangolins, snakes and turtles have been postulated as intermediate hosts of the novel coronavirus. Here we show that COVID-19 transmission from humans to animals is likely to amplify mutations and, in turn, to re-infect humans with deadlier mutants.
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Dates et versions

hal-03255752 , version 1 (09-06-2021)

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Shanshan He, Jie Han, Eric Lichtfouse. Backward transmission of COVID-19 from humans to animals may propagate reinfections and induce vaccine failure. Environmental Chemistry Letters, 2021, 19 (2), pp.763 - 768. ⟨10.1007/s10311-020-01140-4⟩. ⟨hal-03255752⟩
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