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Article Dans Une Revue Annales de l'Institut Pasteur. Immunology Année : 1988

Structure and function of a thymic peptide is mimicked by Plasmodium falciparum peptides

Résumé

Numerous Plasmodium falciparum antigens contain repetitive amino acid sequences. Two blood stage antigens, Pf11-1 and Pf332, were characterized in our laboratories and present high cross-reactivities, defining a family of cross-reacting antigens. In this report, we show that amino acid sequence homologies might explain these cross-reactivities, but that they extend to polypeptides from the host, namely thymosin-alpha 1 (T alpha 1). An antiserum raised in chickens and Saimiri monkeys against the synthetic Pf11-1 peptide cross-reacts with synthetic T alpha 1. Synthetic Pf11-1 and Pf332 peptides share some of the biological activities of T alpha 1. These results are discussed with respect to the mechanisms devised by malaria parasites for escape from the host immune response.

Dates et versions

hal-03246327 , version 1 (02-06-2021)

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P. Dubois, M. Dardenne, T. Fandeur, O. Mercereau-Puijalon, D. Mattei, et al.. Structure and function of a thymic peptide is mimicked by Plasmodium falciparum peptides. Annales de l'Institut Pasteur. Immunology, 1988, 139 (5), pp.557-567. ⟨10.1016/0769-2625(88)90100-6⟩. ⟨hal-03246327⟩
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