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Communication Dans Un Congrès Année : 2020

Development of a hifu treatment using a toroidal transducer for pancreatic adenocarcinoma: Preliminary in vivo study

Résumé

Pancreatic adenocarcinoma is one of the most aggressive cancer. Regardless of the treatment used, the survival rate after 5 years is lower than 6%. Toroidal transducers can treat up to 60 cm3 of tissues in 370 seconds without the need to displace the HIFU probe. In this study, which included fourteen pigs, we evaluated in vivo the use of this device for treating the pancreas and peripancreatic vessels. The device was used intra-operatively. The transducer, working at 2.5MHz, has a toroidal shape with a radius of curvature of 70 mm focusing on a circle of 30 mm. An ultrasound-imaging probe working at 7.5 MHz was placed in the center of the HIFU transducer. Ablations were created in 440 seconds using an acoustic power of 85 or 100 watts. In total eight pigs were included in this study. Eight lesions were created in the pancreas and around peri-pancreatic vessels and observed immediately after treatment. Homogenous ablations were obtained in all cases and were confirmed histologically. The average diameter of the pancreatic ablations was 33.1 � 5.0 mm. These ablations were also homogeneous all around the peripancreatic artery and without occlusion as confirmed by Doppler examination. Using this toroidal HIFU transducer it is possible to treat the most challenging region of the pancreas and its surrounding vessels without any occlusion. This may allow to treat locally advanced pancreatic tumors which are the main contra-indication to curative resection.

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Dates et versions

hal-03242409 , version 1 (31-05-2021)

Identifiants

Citer

Celia Cilleros, Aurélien Dupré, Jérémy Vincenot, David Melodelima. Development of a hifu treatment using a toroidal transducer for pancreatic adenocarcinoma: Preliminary in vivo study. Forum Acusticum, Dec 2020, Lyon, France. pp.2691-2691, ⟨10.48465/fa.2020.0134⟩. ⟨hal-03242409⟩
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