Access to 12-Membered Cyclic ortho , meta -Diarylheptanoids: Total Synthesis of Actinidione via Isomyricanone
Résumé
We describe herein the first access to 12-membered cyclic [7,0]ortho,meta-diarylheptanoids. The key features of the synthesis include both a Suzuki-Miyaura coupling and a ring closing metathesis. Actinidione, a promising natural product, along with a bioactive tetracyclic derivative were obtained in 14 steps for the first time from cheap commercially available substrates with an overall yield of 18-21%. Our modus operandi complies with the principles of the synthesis ideality by using notably strategic reactions.
Domaines
Chimie
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Revised manuscrit jo-2020-02489w Sabine CHOPPIN def.pdf (628.6 Ko)
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