Nonoptimal Vaginal Microbiota after Azithromycin Treatment for Chlamydia trachomatis Infection - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Infectious Diseases Année : 2020

Nonoptimal Vaginal Microbiota after Azithromycin Treatment for Chlamydia trachomatis Infection

Bing Ma
Paweł Gajer
  • Fonction : Auteur
Michael S. Humphrys
  • Fonction : Auteur
Mishka Terplan
  • Fonction : Auteur
Katrina S. Mark
  • Fonction : Auteur
Larry J. Forney
  • Fonction : Auteur
Rebecca M. Brotman
Patrik M. Bavoil
  • Fonction : Auteur
Jacques Ravel
  • Fonction : Auteur correspondant
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Résumé

We characterized the composition and structure of the vaginal microbiota in a cohort of 149 women with genital Chlamydia trachomatis infection at baseline who were followed quarterly for 9 months after antibiotic treatment. At time of diagnosis, the vaginal microbiota was dominated by Lactobacillus iners or a diverse array of bacterial vaginosis-associated bacteria including Gardnerella vaginalis. Interestingly, L. iners-dominated communities were most common after azithromycin treatment (1 g monodose), consistent with the observed relative resistance of L. iners to azithromycin. Lactobacillus iners-dominated communities have been associated with increased risk of C. trachomatis infection, suggesting that the impact of antibiotic treatment on the vaginal microbiota could favor reinfections. These results provide support for the dual need to account for the potential perturbing effect(s) of antibiotic treatment on the vaginal microbiota, and to develop strategies to protect and restore optimal vaginal microbiota.
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Origine : Publication financée par une institution
Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification

Dates et versions

hal-03228157 , version 1 (10-06-2021)

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Jeanne Tamarelle, Bing Ma, Paweł Gajer, Michael S. Humphrys, Mishka Terplan, et al.. Nonoptimal Vaginal Microbiota after Azithromycin Treatment for Chlamydia trachomatis Infection. Journal of Infectious Diseases, 2020, 221 (4), pp.627-635. ⟨10.1093/infdis/jiz499⟩. ⟨hal-03228157⟩
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