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Article Dans Une Revue Annales de Biologie Clinique Année : 2021

Troponin T cardiac analysis: clinical cases of the limits of its cardiospecificity

Illustrations cliniques d’un manque de cardiospécificité du dosage de troponine T hypersensible

Résumé

Introduction - Myositis are systemic diseases, in which heart damage is possible. Cardiac troponin T is often found to be defective to detect cardiac involvement. Observation - We report cases of two patients with a myositis. Diagnosis was retained based on muscle pain, increase in serum creatinine kinase, and inflammatory muscle damage on MRI. Histology confirmed the diagnosis for one of the two patients. Cardiac troponin T was measured in both patients, to detect myocardial involvement. Despite a serum elevation of this marker, cardiological assessment remained negative (electrocardiogram, cardiac ultrasound, cardiac MRI). Cardiac troponin I was normal in serum because of the absence of correlation with peripheral muscle involvement. Conclusion - Cardiac troponin T is correlated with muscle involvement in patients with myositis. Cardiac troponin I should be preferred because of a better specificity.
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Dates et versions

hal-03223963 , version 1 (11-05-2021)

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Valentin Coirier, Romain Pelletier, Martine Sébillot, Charles R Lefèvre, Lucas Peltier, et al.. Illustrations cliniques d’un manque de cardiospécificité du dosage de troponine T hypersensible. Annales de Biologie Clinique, 2021, 79 (2), pp.176-180. ⟨10.1684/abc.2021.1637⟩. ⟨hal-03223963⟩
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