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Article Dans Une Revue Biochemical and Biophysical Research Communications Année : 2005

SMHS1 is involved in oxidative/glycolytic-energy metabolism balance of muscle fibers

Résumé

With the aim of finding important mediators of muscle atrophy, we cloned SMHS1, a novel gene that was found to be upregulated in rat soleus muscle atrophied by restriction of activity. The SMHS1 amino acid sequence shares 65% similarity with RTP801—which is a cellular stress response protein regulated by HIF-1—but SMHS1 expression was demonstrated to be independent of HIF-1. SMHS1 was found to be mainly expressed in skeletal muscle, and comparisons of its expression in atrophied versus hypertrophied muscles and in oxidative versus glycolytic muscles suggested that SMHS1 contributes to the muscle energy metabolism phenotypes.
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hal-03219822 , version 1 (28-09-2021)

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Didier Pisani, Lilian Leclerc, Gisèle Jarretou, Jean-François Marini, Claude Dechesne. SMHS1 is involved in oxidative/glycolytic-energy metabolism balance of muscle fibers. Biochemical and Biophysical Research Communications, 2005, 326 (4), pp.788-793. ⟨10.1016/j.bbrc.2004.11.111⟩. ⟨hal-03219822⟩
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