Article Dans Une Revue Journal of Natural Products Année : 2019

Structural Characterization and Anti-infective Activity of 9,10-Seco-29-norcycloartane Glycosides Isolated from the Flowers of the Peruvian Medicinal Plant Cordia lutea

Résumé

Six new secocycloartane glycosides were isolated from the ethanol extract of the flowers of Cordia lutea Lam. on the basis of bioassay-guided fractionation. Their structures were determined by the application of NMR and MS data analyses together with X-ray crystallographic analyses for compounds 1 and 2. Compounds 1-6 represent the first examples of 9,10-seco-29-norcycloartane glycosides. These compounds showed significant in vitro anti-Helicobacter pylori activity, and no activity against either Escherichia coli or Pseudomonas aeruginosa. Significant activity was observed for 5 and 6 against Staphylococcus aureus. All compounds displayed weak cytotoxicity against RAW 264.7 cells. The in vitro antileishmanial and antiplasmodial activities of 1-6 were also evaluated.

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hal-03210093 , version 1 (27-04-2021)

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Inés Castro, Nicolas Fabre, Sandra Bourgeade-Delmas, Nathalie Saffon, Chloé Gandini, et al.. Structural Characterization and Anti-infective Activity of 9,10-Seco-29-norcycloartane Glycosides Isolated from the Flowers of the Peruvian Medicinal Plant Cordia lutea. Journal of Natural Products, 2019, 82 (12), pp.3233-3241. ⟨10.1021/acs.jnatprod.9b00149⟩. ⟨hal-03210093⟩
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