Communication Dans Un Congrès Année : 2013

BIODISTRIBUTION OF siRNA DELIVERED WITH CHITOSAN-DECORATED POLY(ISOBUTYLCYANOACRYLATE) NANOPARTICLES

Résumé

This work explored biodistribution of the siRNA and that of the nanoparticle carrier after an intravenous administration to mice xenografted with a model tumor of Ewing sarcoma. The chitosan-decorated poly(isobutylcyanoacrylate) nanoparticles considered in this work could deliver the siRNA in the tumor in agreement with their own distribution in the tumor xenografted in mice. The addition of a targeting ligand to the nanoparticles increased further the accumulation of the delivery platform in the tumor.

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hal-03194771 , version 1 (09-04-2021)

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  • HAL Id : hal-03194771 , version 1

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A L Ramon, J R Bertrand, C Zandanel, Christine Vauthier, C Malvy. BIODISTRIBUTION OF siRNA DELIVERED WITH CHITOSAN-DECORATED POLY(ISOBUTYLCYANOACRYLATE) NANOPARTICLES. : Abstract book of the 16th International Symposium on Recent Advances in Drug Delivery Systems. Salt Lake City, UT, USA,, Feb 2013, Salt Lake City, UT, United States. pp.Abstract #66. ⟨hal-03194771⟩
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