Article Dans Une Revue European journal of cancer Année : 2018

Multidisciplinary development of the Geriatric Core Dataset for clinical research in older patients with cancer: A French initiative with international survey

E. Paillaud
  • Fonction : Auteur
P. Soubeyran
  • Fonction : Auteur
P. Caillet
T. Cudennec
  • Fonction : Auteur
E. Brain
  • Fonction : Auteur
C. Terret
  • Fonction : Auteur
L. Mourey
  • Fonction : Auteur
T. Aparicio
  • Fonction : Auteur
F. Pamoukdjian
  • Fonction : Auteur
R. A. Audisio
  • Fonction : Auteur
S. Rostoft
  • Fonction : Auteur
A. Hurria
  • Fonction : Auteur
Carine Bellera

Résumé

BACKGROUND: To define a core set of geriatric data to be methodically collected in clinical cancer trials of older adults, enabling comparison across trials. PATIENTS AND METHODS: Following a consensus approach, a panel of 14 geriatricians from oncology clinics identified seven domains of importance in geriatric assessment. Based on the international recommendations, geriatricians selected the mostly commonly used tools/items for geriatric assessment by domain (January-October 2015). The Geriatric Core Dataset (G-CODE) was progressively developed according to RAND appropriateness ratings and feedback during three successive Delphi rounds (July-September 2016). The face validity of the G-CODE was assessed with two large panels of health professionals (55 national and 42 international experts) involved both in clinical practice and cancer trials (March-September 2017). RESULTS AND DISCUSSION: After the last Delphi round, the tools/items proposed for the G-CODE were the following: (1) social assessment: living alone or support requested to stay at home; (2) functional autonomy: Activities of Daily Living (ADL) questionnaire and short instrumental ADL questionnaire; (3) mobility: Timed Up and Go test; (4) nutrition: weight loss during the past 6 months and body mass index; (5) cognition: Mini-Cog test; (6) mood: mini-Geriatric Depression Scale and (7) comorbidity: updated Charlson Comorbidity Index. More than 70% of national experts (42 from 20 cities) and international experts (31 from 13 countries) participated. National and international surveys showed good acceptability of the G-CODE. Specific points discussed included age-year cut-off, threshold of each tool/item and information about social support, but no additional item was proposed. CONCLUSION: We achieved formal consensus on a set of geriatric data to be collected in cancer trials of older patients. The dissemination and prospective use of the G-CODE is needed to assess its utility.

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Dates et versions

hal-03194137 , version 1 (09-04-2021)

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Citer

E. Paillaud, P. Soubeyran, P. Caillet, T. Cudennec, E. Brain, et al.. Multidisciplinary development of the Geriatric Core Dataset for clinical research in older patients with cancer: A French initiative with international survey. European journal of cancer, 2018, 103, pp.61-68. ⟨10.1016/j.ejca.2018.07.137⟩. ⟨hal-03194137⟩
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