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Article Dans Une Revue Current Pharmaceutical Biotechnology Année : 2007

Ultrasound-directed drug delivery

Résumé

It has been proven, that the cellular uptake of drugs and genes is increased, when the region of interest is under ultrasound insonification, and even more when a contrast agent is present. This increased uptake has been attributed to the formation of transient porosities in the cell membrane, which are big enough for the transport of drugs into the cell (sonoporation). Owing to this technique, new ultrasound contrast agents that incorporate a therapeutic compound have become of interest. Combining ultrasound contrast agents with therapeutic substances may lead to a simple and economic method to instantly cure upon diagnosis, using conventional echo machines. There are two hypotheses for explaining the sonoporation phenomenon, the first being microbubble oscillations near a cell membrane, the second being microbubble jetting through the cell membrane. Based on modeling, high-speed photography, and recent cellular uptake measurements, it is concluded that microbubble jetting behavior can be excluded as the dominant sonoporation mechanism.
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Dates et versions

hal-03193321 , version 1 (09-04-2021)

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Michiel Postema, Odd Helge Gilja. Ultrasound-directed drug delivery. Current Pharmaceutical Biotechnology, 2007, 8 (6), pp.355-361. ⟨10.2174/138920107783018453⟩. ⟨hal-03193321⟩
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