This book constitutes the thoroughly refereed post-conference proceedings of the 11th International Conference on High Performance Computing for Computational Science, VECPAR 2014, held in Eugene, OR, USA, in June/July 2014. The 25 papers presented were carefully reviewed and selected of numerous submissions. The papers are organized in topical sections on algorithms for GPU and manycores, large-scale applications, numerical algorithms, direct/hybrid methods for solving sparse matrices, performance tuning. The volume also contains the papers presented at the 9th International Workshop on Automatic Performance Tuning.