We employ a novel methodology to simulate the irradiation of Sodium cooled Fast Reactors (SFR) subassemblies. The proposed approach allows considering the coupling between key thermal–hydraulic and thermomechanical phenomena, which is usually neglected in traditional simulation methods. Comparisons between results obtained from coupled and uncoupled methodologies show that the latter can significantly over predict the stresses and the strains of highly irradiated fuel bundles. Additionally, we explore different options for the pin mechanical modeling. In particular, we show that a relatively simple beam-based finite element model for the fuel pins can be used to efficiently compute swelling and irradiation creep strains averaged over the cross section of the fuel claddings. However, if a prediction of the cladding swelling gradients is needed, the beam model must be replaced by a more computationally expensive 3D fuel pin model. An efficient method to estimate the fuel cladding temperature evolution based on a limited number of Computational Fluid Dynamics (CFD) simulations is also presented in this work, and its performance is evaluated. Finally, a numerical benchmark against the state-of-the-art coupled code system for the simulation of SFR subassemblies is presented. This benchmark shows that the proposed coupled methodology allows obtaining results that are in good agreement with the reference methodology. However, two clear advantages of the proposed methodology were identified. Firstly, the use of detailed CFD simulations in our methodology, compared to the lower resolution thermal-hydraulic model employed in the state-of-the-art approach. Secondly, considering the reduction of the coolant mass flow rate caused by the fuel bundle deformation, neglected in the pre-existing approach, which is shown in this work to have a potentially large impact on the coolant temperature distribution