A Small Multidrug Resistance-like Transporter Involved in the Arabinosylation of Arabinogalactan and Lipoarabinomannan in Mycobacteria*
Résumé
Background: (Glyco)lipid translocation across the plasma membrane plays a pivotal role in the biogenesis of the mycobacterial cell envelope. Results: The SMR-likes transporter Rv3789 appears to be involved in reorienting decaprenol phosphate arabinose to the periplasm. Conclusion: Rv3789 participates in the buildup of the arabinan domains of arabinogalactan and lipoarabinomannan. Significance: This is the first lipid-linked sugar translocase ever identified in mycobacteria.
Domaines
Biochimie, Biologie MoléculaireOrigine | Publication financée par une institution |
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