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Article Dans Une Revue European Journal of Cancer Année : 2004

Detection of cervical precancer and cancer in a hospital population

Résumé

The aim was to determine the relevance of human papillomavirus (HPV) testing in identifying high-grade cervical intraepithelial neoplasia or worse (CIN2/3+) in a hospital population (n=3574) characterised by a high rate of cytological abnormalities and high-risk HPV infections. According to the results of the initial Papanicolaou and HPV test, women were directly referred for colposcopy/biopsy or recalled for a control visit. Sensitivity and specificity were corrected for verification bias. HPV-testing sensitivity was 94.3%, higher than that of cytological testing at any cut-off point (65.1%-86.8%), while specificity was greater for cytology than for HPV testing (99.3% or 91.8% versus 83.4%). The combination of both tests allowed 100% sensitivity and negative predictive value. We conclude that HPV testing is a relevant tool for the detection of cervical disease. The best way of combining cytology and HPV detection in screening programmes should be evaluated in large-scale studies.

Domaines

Cancer

Dates et versions

hal-03172567 , version 1 (17-03-2021)

Identifiants

Citer

Jean-Luc Pretet, V. Dalstein, D. Riethmuller, J.L. Sautière, J.L. Pretet, et al.. Detection of cervical precancer and cancer in a hospital population. European Journal of Cancer, 2004, 40 (8), pp.1225-1232. ⟨10.1016/j.ejca.2004.01.021⟩. ⟨hal-03172567⟩

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