Non‐alcoholic fatty liver disease in a sample of individuals with bipolar disorders: results from the FACE‐BD cohort - Archive ouverte HAL Access content directly
Journal Articles Acta Psychiatrica Scandinavica Year : 2021

Non‐alcoholic fatty liver disease in a sample of individuals with bipolar disorders: results from the FACE‐BD cohort

Raoul Belzeaux
Frank Bellivier
Joséphine Loftus
  • Function : Author
Caroline Dubertret
  • Function : Author
Sebastien Gard
  • Function : Author
Chantal Henry
  • Function : Author
Pierre-Michel Llorca
Raymund Schwan
Mircea Polosan
  • Function : Author
  • PersonId : 859213
Ludovic Samalin
  • Function : Author
Bruno Etain

Abstract

Objective: Non-Alcoholic fatty liver disease (NAFLD) is becoming the most common liver disease in Western populations. While obesity and metabolic abnormalities are highly frequent in bipolar disorders (BD), no studies have been performed to estimate the prevalence of NALFD in individuals with BD. The aim of our study is to estimate the prevalence of NAFLD and to identify the potential associated risk factors in a large sample of BD individuals. Methods: Between 2009 and 2019, 1969 BD individuals from the FACE-BD cohort were included. Individuals with liver diseases, Hepatitis B or C, and current alcohol use disorders were excluded from the analyses. A blood sample was drawn from participants. Screening of NAFLD was determined using fatty liver index (FLI). Individuals with FLI> 60 were considered as having NAFLD. Results: The prevalence of NAFDL in this sample was estimated at 28.4%. NAFLD was observed in 40% of men and 21% of women. NAFLD was independently associated with older age, male gender, sleep disturbances, and current use of atypical antipsychotics or anxiolytics. As expected, the prevalence of NALFD was also higher in individuals with overweight and in those with metabolic syndrome. Conclusions: This study reinforces the view that individuals with BD are highly vulnerable to metabolic and cardiovascular diseases. The prevalence of NAFLD in individuals with BD was two times higher than the prevalence reported in the general population. The regular screening of the MetS in individuals with BD should be therefore complemented by the additional screening of NAFLD among these vulnerable individuals.
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Dates and versions

hal-03166629 , version 1 (11-03-2021)

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Ophelia Godin, Marion Leboyer, Raoul Belzeaux, Frank Bellivier, Joséphine Loftus, et al.. Non‐alcoholic fatty liver disease in a sample of individuals with bipolar disorders: results from the FACE‐BD cohort. Acta Psychiatrica Scandinavica, 2021, 143 (1), pp.82-91. ⟨10.1111/acps.13239⟩. ⟨hal-03166629⟩
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