Early-Life Environmental Exposures and Childhood Obesity: An Exposome-Wide Approach - Archive ouverte HAL
Article Dans Une Revue Environmental Health Perspectives Année : 2020

Early-Life Environmental Exposures and Childhood Obesity: An Exposome-Wide Approach

Martine Vrijheid
Serena Fossati
  • Fonction : Auteur
Léa Maitre
  • Fonction : Auteur
Sandra Márquez
  • Fonction : Auteur
Theano Roumeliotaki
  • Fonction : Auteur
Lydiane Agier
  • Fonction : Auteur
Sandra Andrusaityte
  • Fonction : Auteur
Solène Cadiou
  • Fonction : Auteur
Maribel Casas
  • Fonction : Auteur
Montserrat de Castro
  • Fonction : Auteur
Audrius Dedele
  • Fonction : Auteur
David Donaire-Gonzalez
  • Fonction : Auteur
Regina Grazuleviciene
  • Fonction : Auteur
Line Haug
  • Fonction : Auteur
Rosemary Mceachan
  • Fonction : Auteur
Helle Margrete Meltzer
  • Fonction : Auteur
Eleni Papadopouplou
  • Fonction : Auteur
Oliver Robinson
  • Fonction : Auteur
Amrit Sakhi
  • Fonction : Auteur
Jordi Sunyer
  • Fonction : Auteur
Per Schwarze
  • Fonction : Auteur
Ibon Tamayo-Uria
  • Fonction : Auteur
Jose Urquiza
  • Fonction : Auteur
Marina Vafeiadi
  • Fonction : Auteur
Antonia Valentin
  • Fonction : Auteur
Charline Warembourg
  • Fonction : Auteur
John Wright
  • Fonction : Auteur
Mark Nieuwenhuijsen
Cathrine Thomsen
  • Fonction : Auteur
Xavier Basagaña
  • Fonction : Auteur
Rémy Slama
Leda Chatzi
  • Fonction : Auteur

Résumé

Background: Chemical and nonchemical environmental exposures are increasingly suspected to influence the development of obesity, especially during early life, but studies mostly consider single exposure groups. Objectives: Our study aimed to systematically assess the association between a wide array of early-life environmental exposures and childhood obesity, using an exposome-wide approach. Methods: The HELIX (Human Early Life Exposome) study measured child body mass index (BMI), waist circumference, skinfold thickness, and body fat mass in 1,301 children from six European birth cohorts age 6–11 y. We estimated 77 prenatal exposures and 96 childhood exposures (cross-sectionally), including indoor and outdoor air pollutants, built environment, green spaces, tobacco smoking, and biomarkers of chemical pollutants (persistent organic pollutants, metals, phthalates, phenols, and pesticides). We used an exposure-wide association study (ExWAS) to screen all exposure–outcome associations independently and used the deletion-substitution-addition (DSA) variable selection algorithm to build a final multiexposure model. Results: The prevalence of overweight and obesity combined was 28.8%. Maternal smoking was the only prenatal exposure variable associated with higher child BMI (z-score increase of 0.28, 95% confidence interval: 0.09, 0.48, for active vs. no smoking). For childhood exposures, the multiexposure model identified particulate and nitrogen dioxide air pollution inside the home, urine cotinine levels indicative of secondhand smoke exposure, and residence in more densely populated areas and in areas with fewer facilities to be associated with increased child BMI. Child blood levels of copper and cesium were associated with higher BMI, and levels of organochlorine pollutants, cobalt, and molybdenum were associated with lower BMI. Similar results were found for the other adiposity outcomes. Discussion: This first comprehensive and systematic analysis of many suspected environmental obesogens strengthens evidence for an association of smoking, air pollution exposure, and characteristics of the built environment with childhood obesity risk. Cross-sectional biomarker results may suffer from reverse causality bias, whereby obesity status influenced the biomarker concentration. https://doi-org.proxy.insermbiblio.inist.fr/10.1289/EHP5975

Dates et versions

hal-03166192 , version 1 (11-03-2021)

Identifiants

Citer

Martine Vrijheid, Serena Fossati, Léa Maitre, Sandra Márquez, Theano Roumeliotaki, et al.. Early-Life Environmental Exposures and Childhood Obesity: An Exposome-Wide Approach. Environmental Health Perspectives, 2020, 128 (6), pp.067009. ⟨10.1289/EHP5975⟩. ⟨hal-03166192⟩

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