An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism
Résumé
Highlights d Glutamine-dependent OXPHOS drives early erythroid differentiation d OXPHOS-induced ROS inhibit erythroblast enucleation d IDH1 downregulation augments ROS, leading to pathological erythroid differentiation d Vitamin C rescues erythroid differentiation under conditions of oxidative stress
Domaines
Sciences du Vivant [q-bio]Origine | Fichiers éditeurs autorisés sur une archive ouverte |
---|