In electrophysiological measurements, a recording electrode is located in an electric field and has a certain electric potential value. Each measured signal is a potential difference between two electrodes, a measuring electrode and a so-called reference electrode. This reference electrode is not located at infinity and outside of any electric field, thus its electric potential is found in the measured signals. In order to isolate the local activity of the recorded structure, it is necessary to understand the relationships between the different contributors at the electrode level and separate these different activities. In this paper, we focus on the particular setup of Behnke-Fried micro-electrodes. We propose to adapt a previous re-referencing method for separating local and distant propagated activities taking into account the non-stationarity of the signals and the particular geometry of these microelectrodes. We demonstrate, on realistically simulated signals, that the new re-ref erencing procedure improves the preprocessing of these signals and might help deeper interpretation.