The French West Indies are periodically affected by North African dust episodes (NADE) resulting in PM10 concentrations exceeding air quality standards. The aim of the present study was to decipher the PM10 chemical profile during NADE over Guadeloupe. PM10 samples were collected daily at a rural site and an urban site during five episodes between April and October in 2017. During these events, the median PM10 mass concentrations were, on average, 2 to 5 times higher than in the post-episode baseline period. Sampled filters were analyzed for their quantification of chemical constituents including carbonaceous fractions (elemental and organic carbon, EC/OC), anions/cations and levoglucosan, 51 elements, and 57 selected organic species. An orthogonal partial least squares discriminant analysis (OPLS-DA) was conducted to identify the specific chemical profile of PM10 during NADE: 16 elements were identified as the most discriminant between the NADE and the control samples with mass concentration levels twice as high during a NADE. Among them, only two (Mn and V) are classified as emerging pollutant while no limit values exist for the other ones. The extensive characterization of the NADE PM10 chemical profile we performed is a key step to assess the chemical exposure of French West Indies populations during such events.