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Article Dans Une Revue Alzheimer's Research and Therapy Année : 2021

Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer's disease

Malo Gaubert
  • Fonction : Auteur
Catharina Lange
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  • PersonId : 1091187
Antoine Garnier-Crussard
  • Fonction : Auteur
Theresa Köbe
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Salma Bougacha
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Julie Gonneaud
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Robin de Flores
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Clémence Tomadesso
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Florence Mézenge
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Brigitte Landeau
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Vincent de La Sayette
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Miranka Wirth
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  • PersonId : 1091188

Résumé

Background: White matter hyperintensities (WMH) are frequently found in Alzheimer's disease (AD). Commonly considered as a marker of cerebrovascular disease, regional WMH may be related to pathological hallmarks of AD, including beta-amyloid (Aβ) plaques and neurodegeneration. The aim of this study was to examine the regional distribution of WMH associated with Aβ burden, glucose hypometabolism, and gray matter volume reduction. Methods: In a total of 155 participants (IMAP+ cohort) across the cognitive continuum from normal cognition to AD dementia, FLAIR MRI, AV45-PET, FDG-PET, and T1 MRI were acquired. WMH were automatically segmented from FLAIR images. Mean levels of neocortical Aβ deposition (AV45-PET), temporo-parietal glucose metabolism (FDG-PET), and medial-temporal gray matter volume (GMV) were extracted from processed images using established AD meta-signature templates. Associations between AD brain biomarkers and WMH, as assessed in region-of-interest and voxel-wise, were examined, adjusting for age, sex, education, and systolic blood pressure. Results: There were no significant associations between global Aβ burden and region-specific WMH. Voxel-wise WMH in the splenium of the corpus callosum correlated with greater Aβ deposition at a more liberal threshold. Region-and voxel-based WMH in the posterior corpus callosum, along with parietal, occipital, and frontal areas, were associated with lower temporo-parietal glucose metabolism. Similarly, lower medial-temporal GMV correlated with WMH in the posterior corpus callosum in addition to parietal, occipital, and fontal areas.
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Dates et versions

hal-03144379 , version 1 (17-02-2021)

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Malo Gaubert, Catharina Lange, Antoine Garnier-Crussard, Theresa Köbe, Salma Bougacha, et al.. Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer's disease. Alzheimer's Research and Therapy, 2021, 13 (1), ⟨10.1186/s13195-020-00759-3⟩. ⟨hal-03144379⟩
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