This paper presents a novel approach to design robust and smooth self-scheduled controllers in the framework of structured H-infinity control. The newly available MATLAB-based tool, hinfstruct, is used to tune fixed-structure linear controllers to meet H-infinity constraints. Moreover, multi-model and multi-channel capabilities are exploited in the design of self-scheduled controllers. In this context, we define a priori both controller architecture and gain-scheduling structure. This approach is successfully applied to the longitudinal control of a F-16 Fighting Falcon over the ight envelope under mass and center of gravity uncertainties. After casting the control synthesis into a structured H-infinity problem, the scheduled gains are directly obtained as quadratic polynomial functions of altitude and Mach number. The performance of the designed control systems is validated by numerical simulations.