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Article Dans Une Revue Journal of Combinatorial Chemistry Année : 2000

Soluble Polymer Supported Synthesis of α-Amino Acid Derivatives

Résumé

A Schiff base activated glycine supported on a soluble polymer (poly(ethylene glycol) (PEG)) was readily alkylated with a wide variety of electrophiles in the presence of a carbonate base in acetonitrile. The presence of the polymer provided a phase-transfer catalysis environment which accelerated the reaction. Effects of various carbonate bases and leaving groups have been also studied. Completion of the PEG-supported reaction was obtained without using a large excess of reagents or an extra phase-transfer catalyst, even in the case of unreactive or hindered electrophiles. After cleavage from the polymer, α-amino esters are obtained in good yields.
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Dates et versions

hal-03125693 , version 1 (05-02-2021)

Identifiants

Citer

B. Sauvagnat, Katarzyna Kulig, Frédéric Lamaty, René Lazaro, Jean Martinez. Soluble Polymer Supported Synthesis of α-Amino Acid Derivatives. Journal of Combinatorial Chemistry, 2000, 2 (2), pp.134-142. ⟨10.1021/cc9900605⟩. ⟨hal-03125693⟩
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