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Article Dans Une Revue Clinical Nuclear Medicine Année : 2021

Photopenic Defects in Gliomas With Amino-Acid PET and Relative Prognostic Value

Résumé

The aim is to explore the concept of photopenic defects in newly diagnosed glioma patients with the 2 widely used C-MET and F-FDOPA PET amino acid tracers. Thirty-two C-MET and 26 F-FDOPA PET scans with amino acid PET-negative gliomas were selected in this European multicentric study. Of these gliomas, 16 C-MET and 10 F-FDOPA PET scans with photopenic defects were identified, exhibiting lower mean tumor-to-background ratio as compared with isometabolic gliomas (P < 0.001). Gliomas with photopenic defects had no different progression-free survival than isometabolic gliomas in the whole population (P = 0.40), but shorter progression-free survival in the subgroup of World Health Organization grade II IDH-mutant astrocytomas (35 vs 68 months; P = 0.047).
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Dates et versions

hal-03121952 , version 1 (26-01-2021)

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Timothée Zaragori, Angelo Castello, Eric Guedj, Antoine Girard, Norbert Galldiks, et al.. Photopenic Defects in Gliomas With Amino-Acid PET and Relative Prognostic Value. Clinical Nuclear Medicine, 2021, 46 (1), pp.e36-e37. ⟨10.1097/RLU.0000000000003240⟩. ⟨hal-03121952⟩
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