The Functions of the Demethylase JMJD3 in Cancer - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Molecular Sciences Année : 2021

The Functions of the Demethylase JMJD3 in Cancer

Résumé

Cancer is a major cause of death worldwide. Epigenetic changes in response to external (diet, sports activities, etc.) and internal events are increasingly implicated in tumor initiation and progression. In this review, we focused on post-translational changes in histones and, more particularly, the tri methylation of lysine from histone 3 (H3K27me3) mark, a repressive epigenetic mark often under- or overexpressed in a wide range of cancers. Two actors regulate H3K27 methylation: Jumonji Domain-Containing Protein 3 demethylase (JMJD3) and Enhancer of zeste homolog 2 (EZH2) methyltransferase. A number of studies have highlighted the deregulation of these actors, which is why this scientific review will focus on the role of JMJD3 and, consequently, H3K27me3 in cancer development. Data on JMJD3’s involvement in cancer are classified by cancer type: nervous system, prostate, blood, colorectal, breast, lung, liver, ovarian, and gastric cancers
Fichier principal
Vignette du fichier
ijms-22-00968-v2.pdf (373.79 Ko) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03120209 , version 1 (28-05-2021)

Licence

Paternité

Identifiants

Citer

Anna Sanchez, Fatma Zohra Houfaf Khoufaf, Mouhamed Idrissou, Frédérique Penault-Llorca, Yves-Jean Bignon, et al.. The Functions of the Demethylase JMJD3 in Cancer. International Journal of Molecular Sciences, 2021, 22 (2), pp.968. ⟨10.3390/ijms22020968⟩. ⟨hal-03120209⟩
92 Consultations
65 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More