Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2006

Design and synthesis of cyclic and linear peptide-agarose tools for baiting interacting protein partners of GPCRs

Résumé

A ligation strategy for the synthesis of cyclic and linear peptides covalently linked to agarose beads designed as baits to identify new interacting partners of intracellular loops of the V2 vasopressin receptor, a member of the G-protein-coupled receptor family, is reported. The peptide-resin conjugates were subsequently shown to interact specifically with a fraction of proteins present in cellular lysates.

Dates et versions

hal-03117141 , version 1 (20-01-2021)

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Sébastien Granier, Frédéric Jean-Alphonse, Hélène Déméné, Gilles Guillon, Robert Pascal, et al.. Design and synthesis of cyclic and linear peptide-agarose tools for baiting interacting protein partners of GPCRs. Bioorganic and Medicinal Chemistry Letters, 2006, 16 (3), pp.521-524. ⟨10.1016/j.bmcl.2005.10.061⟩. ⟨hal-03117141⟩
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