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Article Dans Une Revue Scientific Reports Année : 2019

Proton transport modeling in a realistic biological environment by using TILDA-V

Résumé

Whether it is in radiobiology to identify DNA lesions or in medicine to adapt the radiotherapeutic protocols, a detailed understanding of the radiation-induced interactions in living matter is required. Monte Carlo track-structure codes have been successfully developed to describe these interactions and predict the radiation-induced energy deposits at the nanoscale level in the medium of interest. in this work, the quantum-mechanically based Monte Carlo track-structure code TILDA-V has been used to compute the slowing-down of protons in water and DNA. Stopping power and range are then reported and compared with existing data. Then, a first application of TILDA-V to cellular irradiations is also reported in order to highlight the absolute necessity of taking into account a realistic description of the cellular environment in microdosimetry.
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hal-03114625 , version 1 (19-01-2021)

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Mario Alcocer-Avila, Michele A Quinto, Juan M Monti, Roberto D Rivarola, Christophe Champion. Proton transport modeling in a realistic biological environment by using TILDA-V. Scientific Reports, 2019, 9, ⟨10.1038/s41598-019-50270-5⟩. ⟨hal-03114625⟩
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