An Information-Theoretic Analysis of Genetics, Gender and Age in Cancer Patients - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2008

An Information-Theoretic Analysis of Genetics, Gender and Age in Cancer Patients

Résumé

Germline genetics, gender and hormonal-signaling pathways are all well described modifiers of cancer risk and progression. Although an improved understanding of how germline genetic variants interact with other cancer risk factors may allow better prevention and treatment of human cancer, measuring and quantifying these interactions is challenging. In other areas of research, Information Theory has been used to quantitatively describe similar multivariate interactions. We implemented a novel information-theoretic analysis to measure the joint effect of a high frequency germline genetic variant of the p53 tumor suppressor pathway (MDM2 SNP309 T/G) and gender on clinical cancer phenotypes. This analysis quantitatively describes synergistic interactions among gender, the MDM2 SNP309 locus, and the age of onset of tumorigenesis in p53 mutation carriers. These results offer a molecular and genetic basis for the observed sexual dimorphism of cancer risk in p53 mutation carriers and a model is proposed that suggests a novel cancer prevention strategy for p53 mutation carriers.

Dates et versions

hal-03106931 , version 1 (12-01-2021)

Identifiants

Citer

Gurinder Singh Atwal, Raúl Rabadán, Guillermina Lozano, Louise Strong, Mariëlle Ruijs, et al.. An Information-Theoretic Analysis of Genetics, Gender and Age in Cancer Patients. PLoS ONE, 2008, 3 (4), pp.e1951. ⟨10.1371/journal.pone.0001951⟩. ⟨hal-03106931⟩
23 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More