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Article Dans Une Revue Biology of the Cell Année : 2019

Motile ciliogenesis and the mitotic prism

Adel Al Jord
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Nathalie Spassky
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Résumé

Motile cilia of epithelial multiciliated cells transport vital fluids along organ lumens to promote essential respiratory, reproductive and brain functions. Progenitors of multiciliated cells undergo massive and coordinated organelle remodelling during their differentiation for subsequent motile ciliogenesis. Defects in multiciliated cell differentiation lead to severe cilia-related diseases by perturbing cilia-based flows. Recent work designated the machinery of mitosis as the orchestrator of the orderly progression of differentiation associated with multiple motile cilia formation. By examining the events leading to motile ciliogenesis with a methodological prism of mitosis, we contextualise and discuss the recent findings to broaden the spectrum of questions related to the differentiation of mammalian multiciliated cells.
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Dates et versions

hal-03103287 , version 1 (26-02-2024)

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Adel Al Jord, Nathalie Spassky, Alice Meunier. Motile ciliogenesis and the mitotic prism. Biology of the Cell, 2019, 111, pp.199 - 212. ⟨10.1111/boc.201800072⟩. ⟨hal-03103287⟩

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