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Article Dans Une Revue Autoimmunity Reviews Année : 2020

The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus

1 UNIVAQ - Università degli Studi dell'Aquila = University of L'Aquila
2 UCBM - Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome
3 Rheumatology, Unit - Department of Medicine [Perugia, Italy]
4 The London School of Medicine & Dentistry, Queen Mary University London, London, UK
5 Sant'Anna University Hospital
6 UNIVAQ - University of L'Aquila [Italy]
7 "Federico II" University of Naples Medical School
8 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
9 University of the Study of Campania Luigi Vanvitelli
10 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
11 Hospital Clínico San Carlos [Madrid, Spain]
12 Department of Rheumatology [Zürich]
13 Helios Department of Rheumatology, Sophie-v.-Boetticher-Straße 1, 39245 Gommern, Germany
14 LaTIM - Laboratoire de Traitement de l'Information Medicale
15 UOC Reumatologia, Presidio Ospedaliero "Santo Spirito", Pescara, Italy
16 University hospital of Zurich [Zurich]
17 UNIPG - Università degli Studi di Perugia = University of Perugia
18 University of Catanzaro
19 Università degli studi di Palermo - University of Palermo
20 San Bortolo Hospital
21 Unipd - Università degli Studi di Padova = University of Padua
22 Rheumatology Unit, Torino
23 Department of Chemistry, University of Toledo
24 Division of Rheumatology [Geneva, Switzerland]
25 University of Barcelona
26 UNIMOL - Università degli Studi del Molise = University of Molise
27 Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
28 UNIBA - Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro
29 University of Rome TorVergata
30 LabEX IGO Immunothérapie Grand Ouest
31 LBAI - Lymphocytes B, Autoimmunité et Immunothérapies
32 Queen Mary University of London
33 School of Medicine and Dentistry, Queen Mary University of London
34 Department of Medicine (DIMED)
35 University of Naples Federico II = Università degli studi di Napoli Federico II
36 The Zabludowicz Center for Autoimmune Diseases
37 Sackler Faculty of Medicine
38 Sechenov First Moscow State Medical University
39 NKUA - National and Kapodistrian University of Athens
40 Department of Pathophysiology, Medical School, University of Athens
Oliver Distler
Annamaria Iagnocco
Salvatore D’angelo
  • Fonction : Auteur

Résumé

Autoimmune diseases (AIDs) share similar serological, clinical, and radiological findings, but, behind these common features, there are different pathogenic mechanisms, immune cells dysfunctions, and targeted organs. In this context, multiple lines of evidence suggest the application of precision medicine principles to AIDs to reduce the treatment failure. Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient, thus it could be a new approach for management of AIDS which considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in choosing the right treatment, the best timing of administration, consequently trying to maximize drug efficacy, and, possibly, reducing adverse events. In this work, the growing body of evidence is summarized regarding the predictive factors for drug response in patients with AIDs, applying the precision medicine principles to provide high-quality evidence for therapeutic opportunities in improving the management of these patients.

Dates et versions

hal-03098438 , version 1 (05-01-2021)

Identifiants

Citer

Roberto Giacomelli, Antonella Afeltra, Elena Bartoloni, Onorina Berardicurti, Michele Bombardieri, et al.. The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus. Autoimmunity Reviews, 2020, pp.102738. ⟨10.1016/j.autrev.2020.102738⟩. ⟨hal-03098438⟩
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