Synergistic anti-fouling and bactericidal poly(ether ether ketone) surfaces via a one-step photomodification - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Materials Science and Engineering: C Année : 2020

Synergistic anti-fouling and bactericidal poly(ether ether ketone) surfaces via a one-step photomodification

Résumé

Implants of poly(ether ether ketone) (PEEK) are gaining importance in surgical bone reconstruction of the skull. As with any implant material, PEEK is susceptible to bacterial contamination and occasionally PEEK implants were removed from patients because of infection. To address this problem, a combination of anti-fouling and bactericidal polymers are grafted onto PEEK. The originality is that anti-fouling (modified poly(ethylene glycol)) and bactericidal (quaternized poly(dimethylaminoethyl acrylate)) moieties are simultaneously and covalently grafted onto PEEK via UV photoinsertion. The functionalized PEEK surfaces are evaluated by water contact angle measurements, FTIR, XPS and AFM. Grafting of anti-fouling and bactericidal polymers significantly reduces Staphylococcus aureus adhesion on PEEK surfaces without exhibiting cytotoxicity in vitro. This study demonstrates that grafting combinations of anti-fouling and bactericidal polymers synergistically prevents bacterial adhesion on PEEK implants. This approach shows clinical relevance as grafting is rapid, does not modify PEEK properties and can be conducted on pre-formed implants.
Fichier principal
Vignette du fichier
MSEC_2020_200_revised.pdf (673.81 Ko) Télécharger le fichier
MSEC_2020_200_SupInfo_revised.pdf (755.33 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03095870 , version 1 (04-01-2021)

Identifiants

Citer

Sytze Buwalda, Stijn Rotman, David Eglin, Fintan Moriarty, Audrey Bethry, et al.. Synergistic anti-fouling and bactericidal poly(ether ether ketone) surfaces via a one-step photomodification. Materials Science and Engineering: C, 2020, 111, pp.110811. ⟨10.1016/j.msec.2020.110811⟩. ⟨hal-03095870⟩
38 Consultations
264 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More