Ito Cells Are Liver-Resident Antigen-Presenting Cells for Activating T Cell Responses - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Immunity Année : 2007

Ito Cells Are Liver-Resident Antigen-Presenting Cells for Activating T Cell Responses

Résumé

Here we identified Ito cells (hepatic stellate cells, HSC), known for storage of vitamin A and participation in hepatic fibrosis, as professional liver-resident antigen-presenting cells (APC). Ito cells efficiently presented antigens to CD1-, major histocompatibility complex (MHC)-I-, and MHC-II-restricted T cells. Ito cells presented lipid antigens to CD1-restricted T lymphocytes such as natural killer T (NKT) cells and promoted homeostatic proliferation of liver NKT cells through interleukin-15. Moreover, Ito cells presented antigenic peptides to CD8 + and CD4 + T cells and mediated crosspriming of CD8 + T cells. Peptide-specific T cells were activated by transgenic Ito cells presenting endogenous neoantigen. Upon bacterial infection, Ito cells elicited antigen-specific T cells and mediated protection. In contrast to other liver cell types that have been implicated in induction of immunological tolerance, our data identify Ito cells as professional intrahepatic APCs activating T cells and eliciting a multitude of T cell responses specific for protein and lipid antigens.
Fichier principal
Vignette du fichier
2007 Immunity Winau Ito.pdf (1.15 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03095868 , version 1 (02-02-2021)

Identifiants

Citer

Florian Winau, Guido Hegasy, Ralf Weiskirchen, Stephan Weber, Cécile Cassan, et al.. Ito Cells Are Liver-Resident Antigen-Presenting Cells for Activating T Cell Responses. Immunity, 2007, 26 (1), pp.117-129. ⟨10.1016/j.immuni.2006.11.011⟩. ⟨hal-03095868⟩
29 Consultations
80 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More