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Article Dans Une Revue Neuron Année : 2013

Inhibition-Induced Theta Resonance in Cortical Circuits

Résumé

Both circuit and single-cell properties contribute to network rhythms. In vitro, pyramidal cells exhibit theta-band membrane potential (subthreshold) resonance, but whether and how subthreshold resonance translates into spiking resonance in freely behaving animals is unknown. Here, we used optogenetic activation to trigger spiking in pyramidal cells or parvalbumin immunoreactive interneurons (PV) in the hippocampus and neocortex of freely behaving rodents. Individual directly activated pyramidal cells exhibited narrow-band spiking centered on a wide range of frequencies. In contrast, PV photoactivation indirectly induced theta-band-limited, excess postinhibitory spiking in pyramidal cells (resonance). PV-inhibited pyramidal cells and interneurons spiked at PV-inhibition troughs, similar to CA1 cells during spontaneous theta oscillations. Pharmacological blockade of hyperpolarization-activated (I h) currents abolished theta resonance. Inhibition-induced thetaband spiking was replicated in a pyramidal cellinterneuron model that included I h. Thus, PV interneurons mediate pyramidal cell spiking resonance in intact cortical networks, favoring transmission at theta frequency.
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Dates et versions

hal-03091575 , version 1 (15-11-2023)

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Eran Stark, Ronny Eichler, Lisa Roux, Shigeyoshi Fujisawa, Horacio G Rotstein, et al.. Inhibition-Induced Theta Resonance in Cortical Circuits. Neuron, 2013, 80, pp.1263 - 1276. ⟨10.1016/j.neuron.2013.09.033⟩. ⟨hal-03091575⟩
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