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Article Dans Une Revue Nature Neuroscience Année : 2017

Sharp wave ripples during learning stabilize the hippocampal spatial map

Lisa Roux
Bo Hu
  • Fonction : Auteur
Ronny Eichler
  • Fonction : Auteur
Eran Stark
  • Fonction : Auteur
György Buzsáki
  • Fonction : Auteur
  • PersonId : 1087056

Résumé

Cognitive representation of the environment requires a stable hippocampal map, but the mechanisms maintaining a given map are unknown. Because sharp wave-ripples (SPW-R) orchestrate both retrospective and prospective spatial information, we hypothesized that disrupting neuronal activity during SPW-Rs affects spatial representation. Mice learned new sets of three goal locations daily in a multiwell maze. We used closed-loop SPW-R detection at goal locations to trigger optogenetic silencing of a subset of CA1 pyramidal neurons. Control place cells (nonsilenced or silenced outside SPW-Rs) largely maintained the location of their place fields after learning and showed increased spatial information content. In contrast, the place fields of SPW-Rsilenced place cells remapped, and their spatial information remained unaltered. SPW-R silencing did not impact the firing rates or proportions of place cells. These results suggest that interference with SPW-R-associated activity during learning prevents stabilization and refinement of hippocampal maps.
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Dates et versions

hal-03091338 , version 1 (08-01-2021)

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Lisa Roux, Bo Hu, Ronny Eichler, Eran Stark, György Buzsáki. Sharp wave ripples during learning stabilize the hippocampal spatial map. Nature Neuroscience, 2017, 20 (6), pp.845-853. ⟨10.1038/nn.4543⟩. ⟨hal-03091338⟩
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