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Article Dans Une Revue Tetrahedron Letters Année : 2019

A simple and versatile method to synthesize N-acylbenzotriazoles

Résumé

An efficient method for the synthesis of N-acyl-benzotriazoles from a wide variety of protected amino acids, as well as from compounds frequently used in drug discovery such as biotin and N-Fmoc polyethylene glycol, has been developed. The reaction of carboxylic acid derivatives with benzotriazole in the presence of T3P_ yielded the corresponding N-acyl-benzotriazoles, which were obtained in high purity following a simple work-up procedure, in most cases via precipitation of the desired product in water.
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Dates et versions

hal-03082020 , version 1 (18-12-2020)

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Guillaume Laconde, Muriel Amblard, Jean Martinez. A simple and versatile method to synthesize N-acylbenzotriazoles. Tetrahedron Letters, 2019, 60 (4), pp.341-343. ⟨10.1016/j.tetlet.2018.12.046⟩. ⟨hal-03082020⟩
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