Inhibition of locus coeruleus neurons by the phencyclidine analog, N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine: evidence for potent indirect adrenoceptor agonist properties - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue European Journal of Pharmacology Année : 1992

Inhibition of locus coeruleus neurons by the phencyclidine analog, N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine: evidence for potent indirect adrenoceptor agonist properties

Karima Chergui
  • Fonction : Auteur
Jean-Louis Brunet
  • Fonction : Auteur
Paul Charléty
  • Fonction : Auteur
Claude Saunier
  • Fonction : Auteur
Michel Buda
  • Fonction : Auteur
Alain Privat
  • Fonction : Auteur
Jacques Vignon
  • Fonction : Auteur
Jean-Marc Kamenka
  • Fonction : Auteur
Guy Chouvet
  • Fonction : Auteur

Résumé

The effects of the phencyclidine derivative, N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine (BTCP), on the electrical activity of noradrenaline (NA) neurons of the locus coeruleus (LC) were studied in halothane-anesthetized rats. Systemic administration of BTCP potently inhibited LC neurons (ID50 of 1.1 +/- 0.1 mg/kg i.v.). This effect was mimicked by local microejection of BTCP into the LC. Both the systemic and local effects of BTCP were blocked by alpha 2-adrenoceptor antagonists and prevented by prior depletion of catecholamines with reserpine. These and other data suggest that BTCP behaves as a potent indirect NA agonist (i.e. via NA re-uptake and/or release systems).

Dates et versions

hal-03066898 , version 1 (15-12-2020)

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Citer

Karima Chergui, Hidéo Akaoka, Jean-Louis Brunet, Paul Charléty, Claude Saunier, et al.. Inhibition of locus coeruleus neurons by the phencyclidine analog, N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine: evidence for potent indirect adrenoceptor agonist properties. European Journal of Pharmacology, 1992, 219 (1), pp.169-172. ⟨10.1016/0014-2999(92)90597-w⟩. ⟨hal-03066898⟩
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