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Article Dans Une Revue Journal of Neuroimmunology Année : 1996

Selective induction of cytokines in mouse brain infected with canine distemper virus: structural, cellular and temporal expression

Anna Bencsik
Christophe Malcus
Pascale Giraudon
  • Fonction : Auteur
Marie-Françoise Belin
  • Fonction : Auteur
Ariette Bernard
  • Fonction : Auteur

Résumé

We have previously shown that, in experimentally inoculated mice, canine distemper virus (CDV), a neurotropic virus, selectively infects certain brain structures (hypothalamus, hippocampus, monoaminergic nuclei, etc). Here we demonstrate that tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 transcripts are selectively expressed in these CDV-targeted structures, except in the dentate gyrus, where cytokines are induced without prior CDV replication. The time-course of TNF-alpha expression vs. viral replication in the hypothalamus was different from that in hippocampus. In addition, we show that a substantial number of neurons express TNF-alpha and IL-6. These findings provide new insights into the possible participation of cytokines in the neurological disorders triggered by CDV infection.

Dates et versions

hal-03066691 , version 1 (15-12-2020)

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Citer

Anna Bencsik, Christophe Malcus, Hidéo Akaoka, Pascale Giraudon, Marie-Françoise Belin, et al.. Selective induction of cytokines in mouse brain infected with canine distemper virus: structural, cellular and temporal expression. Journal of Neuroimmunology, 1996, 65 (1), pp.1-9. ⟨10.1016/0165-5728(95)00173-5⟩. ⟨hal-03066691⟩
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