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Article Dans Une Revue Science Année : 2010

Small Peptides Switch the Transcriptional Activity of Shavenbaby During Drosophila Embryogenesis

Takefumi Kondo
  • Fonction : Auteur
Serge Plaza
Jennifer Zanet
  • Fonction : Auteur
  • PersonId : 1085921
Philippe Valenti
  • Fonction : Auteur
  • PersonId : 1264087
  • IdRef : 270649395
Yoshiko Hashimoto
  • Fonction : Auteur
Satoru Kobayashi
  • Fonction : Auteur
Francois Payre
Yuji Kageyama
  • Fonction : Auteur

Résumé

A substantial proportion of eukaryotic transcripts are considered to be noncoding RNAs because they contain only short open reading frames (sORFs). Recent findings suggest, however, that some sORFs encode small bioactive peptides. Here, we show that peptides of 11 to 32 amino acids encoded by the polished rice (pri) sORF gene control epidermal differentiation in Drosophila by modifying the transcription factor Shavenbaby (Svb). Pri peptides trigger the amino-terminal truncation of the Svb protein, which converts Svb from a repressor to an activator. Our results demonstrate that during Drosophila embryogenesis, Pri sORF peptides provide a strict temporal control to the transcriptional program of epidermal morphogenesis.
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Dates et versions

hal-03064341 , version 1 (14-12-2020)

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Citer

Takefumi Kondo, Serge Plaza, Jennifer Zanet, Emilie Benrabah, Philippe Valenti, et al.. Small Peptides Switch the Transcriptional Activity of Shavenbaby During Drosophila Embryogenesis. Science, 2010, 329 (5989), pp.336-339. ⟨10.1126/science.1188158⟩. ⟨hal-03064341⟩
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