Plasma/target interactions in biomedical applications of cold atmospheric pressure plasmas: Implications for “dose” regulation in treatments
Résumé
The last decade has seen an impressive increase of the research dedicated to the biological applications of low temperature atmospheric pressure plasmas. Medical appli-cations are tacking an increasing place underlined by many clinical trials. They now concern numerous domains, including blood coagulation, dental care, skin decontamination and hygiene, wound and ulcer treatment, dermatology, cancer treatment. Biological applications are also now extended to agriculture and, more recently, to cosmetic. Despite the huge number of in vitro and in vivo experiments, there are still numerous challenges to overcome linked to the nature of the encountered target (biological tissues and materials, organs and their direct environment, liquids) that have a direct effect on the produced plasma itself and on the generated species. That must therefore be taken into account in the applied treatments and complicates the definition of a "plasma dose" expected by many.
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