Direct and Regioselective C(sp3)–H Bond Fluorination of 2-Alkylazaarenes with Selectfluor

Herein, a regioselective and direct mono-fluorination strategy of pyridylic and quinolinic C(sp3)-H bonds was developed under transition metal free conditions with Selectfluor. The reaction was performed under smooth conditions and afforded fluorinated azaheterocycles including 2-methyl pyridines and quinolines in moderate to good yields.

Mots clés

Fluorination azaheterocycle Selectfluor 2-methylpyridines 2-methylquinolines

Domaines

Chimie organique Chimie thérapeutique

Fichier principal

Direct and regioselective C(sp3)-H bond fluorination of 2-alkyl azaarenes with selectfluor.pdf (1 Mo)

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https://hal.science/hal-03061701

Soumis le : jeudi 25 novembre 2021-16:48:57

Dernière modification le : mardi 4 juin 2024-12:22:03

Archivage à long terme le : samedi 26 février 2022-21:45:50

Dates et versions

hal-03061701 , version 1 (25-11-2021)

Identifiants

HAL Id : hal-03061701 , version 1
DOI : 10.1055/s-0040-1706482

Citer

Clothilde Le Guen, Ahmed Mazzah, Maël Penhoat, Patricia Melnyk, Christian Rolando, et al.. Direct and Regioselective C(sp3)–H Bond Fluorination of 2-Alkylazaarenes with Selectfluor. Synthesis: Journal of Synthetic Organic Chemistry, 2020, 53 (6), pp.1157-1162. ⟨10.1055/s-0040-1706482⟩. ⟨hal-03061701⟩

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