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Article Dans Une Revue Nanomaterials Année : 2020

Hydrocarbon-Stapled Peptide Based-Nanoparticles for siRNA Delivery

Résumé

Small interfering RNAs (siRNAs) are promising molecules for developing new therapies based on gene silencing; however, their delivery into cells remains an issue. In this study, we took advantage of stapled peptide technology that has emerged as a valuable strategy to render natural peptides more structured, resistant to protease degradation and more bioavailable, to develop short carriers for siRNA delivery. From the pool of stapled peptides that we have designed and synthesized, we identified non-toxic vectors that were able to efficiently encapsulate siRNA, transport them into the cell and induce gene silencing. Remarkably, the most efficient stapled peptide (JMV6582), is composed of only eight amino-acids and contains only two cationic charges.
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Dates et versions

hal-03053993 , version 1 (11-12-2020)

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Paternité

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Matthieu Simon, Nabila Laroui, Marianne Heyraud, Guillaume Laconde, Lamiaa Mohamed Ahmed Ali, et al.. Hydrocarbon-Stapled Peptide Based-Nanoparticles for siRNA Delivery. Nanomaterials, 2020, 10 (12), pp.2334. ⟨10.3390/nano10122334⟩. ⟨hal-03053993⟩
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