MR to CT synthesis with multicenter data in the pelvic area using a conditional generative adversarial network - Archive ouverte HAL
Article Dans Une Revue Physics in Medicine and Biology Année : 2020

MR to CT synthesis with multicenter data in the pelvic area using a conditional generative adversarial network

Résumé

The establishment of an MRI-only workflow in radiotherapy depends on the ability to generate an accurate synthetic CT (sCT) for dose calculation. Previously proposed methods have used a Generative Adversarial Network (GAN) for fast sCT generation in order to simplify the clinical workflow and reduces uncertainties. In the current paper we use a conditional Generative Adversarial Network (cGAN) framework called pix2pixHD to create a robust model prone to multicenter data. This study included T2-weighted MR and CT images of 19 patients in treatment position from 3 different sites. The cGAN was trained on 2D transverse slices of 11 patients from 2 different sites. Once trained, the network was used to generate sCT images of 8 patients coming from a third site. The Mean Absolute Errors (MAE) for each patient were evaluated between real and synthetic CTs. A radiotherapy plan was optimized on the sCT series and re-calculated on CTs to assess the dose distribution in terms of voxel-wise dose difference and Dose Volume Histograms (DVH) analysis. It takes on average of to generate a complete sCT (88 slices) for a patient on our GPU. The average MAE in HU between the sCT and actual patient CT (within the body contour) is 48.5 ± 6 HU with our method. The maximum dose difference to the target is 1.3%. This study demonstrates that an sCT can be generated in a multicentric context, with fewer pre-processing steps while being fast and accurate.
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Dates et versions

hal-03337416 , version 1 (07-09-2021)

Identifiants

Citer

Kévin Brou Boni, John Klein, Ludovic Vanquin, Antoine Wagner, Thomas Lacornerie, et al.. MR to CT synthesis with multicenter data in the pelvic area using a conditional generative adversarial network. Physics in Medicine and Biology, 2020, 65 (7), pp.075002. ⟨10.1088/1361-6560/ab7633⟩. ⟨hal-03337416⟩
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